畲族Gc、PGM1、AcP1、6-PGD、ADA和AK1的遗传多态性

人类学学报 ›› 1997, Vol. 16 ›› Issue (04): 262-270.

畲族Gc、PGM1、AcP1、6-PGD、ADA和AK1的遗传多态性

卓孝福,郭永建,戴庚孙,尹学念,徐玖瑾,杜若甫

出版日期:1997-12-15 发布日期:1997-12-15

Genetic polymorphism of Gc, PGM1, AcP1 , 6-PGD, ADA and AK1 in She ethnic group in China

Zhuo Xiaofu, Guo Yongjiang, Dai Gengsun, Yin Xuenian, Xu Jiujin, Du Ruofu

Online:1997-12-15 Published:1997-12-15

摘要/Abstract

摘要： 对畲族血浆组特异性成分 ( Gc)、红细胞磷酸葡萄糖变位酶 1 ( PGM1)、酸性磷酸酶 ( AcP1 )、 6-磷酸葡萄糖酸脱氢酶 ( 6-PGD)、腺苷脱氨酶 ( ADA)、腺苷酸激酶 ( AK1) 的遗传多态性进行了研究。Gc与 PGM1是用薄层聚丙烯酰胺凝胶等电聚焦分析的，AcP1、 6-PGD、 ADA 及 AK1是用淀粉凝胶电泳分析的。各基因座的基因频率分别为 Gc* 1F 0. 4722、 Gc* 1S 0. 2421、 Gc* 2 0. 2738; PGM1* 1A 0. 5357、 PGM1* 1B 0. 1627、 PGM1* 2A 0. 1587、 PGM 1* 2B 0. 1429; AcP*1 A 0. 1825、 AcP1* B 0. 8175; 6-PGD* A 0. 9683、 6-PGD* B 0. 0278; ADA* 1 0. 9881、 ADA* 2 0. 0119; AK1* 1 1. 0000。畲族 Gc、 PGM1、 AcP1、 6-PGD和 ADA基因为多态，而 AK1基因为单态。发现 1例带有 6-PGD* R和 3例带有 Gc* 1A2变异等位基因的个体，其中 Gc* 1A2基因频率为 0. 0119, 达到多态水平。

关键词: 遗传多态性;畲族;组特异性成分;磷酸葡萄糖变位酶1;酸性磷酸酶;6－磷酸葡萄糖酸脱氢酶;腺苷脱氨酶;腺苷酸激酶

Abstract: The genentic polymorphism of Gc and PGM 1 w as studied with thin layer polyacryamide gel isoelectric focusing (PAG-IEF) and that of AcP1 , 6-PGD, ADA, and AK1 with starch gel electrophoresis combined with specific staining in She ethnic group in Fujian Province. Their gene frequencies obtained are: Gc* 1F 0. 4722, Gc* 1S 0. 2421, Gc* 2 0. 2738; PGM 1* 1A 0. 5357, PGM 1* 1B 0. 1627, PGM1* 2A 0. 1587, PGM 1* 2B 0. 1429; AcP1* A 0. 1825, AcP1* B 0. 8175; 6-PGD* A 0. 9683, 6-PGD* B 0. 0278; ADA* 1 0. 9881, ADA* 2 0. 0119; and AK1* 1 1. 0000. There is monomorphism in locus of AK1 in She population. Three cases with rare variant allele ( Gc* 1A2) w ere found in Gc with a frequency of 0. 0119, and one case with 6-PGD* R in 6-PGD.

Key words: Polymorphism, She ethnic group, Acid phosphatase, 6-Phosphogluconate dehydrogenase, Adenosine deaminas, Adenylate kinase, Group-specific component

卓孝福,郭永建,戴庚孙,尹学念,徐玖瑾,杜若甫. 畲族Gc、PGM1、AcP1、6-PGD、ADA和AK1的遗传多态性[J]. 人类学学报, 1997, 16(04): 262-270.

Zhuo Xiaofu, Guo Yongjiang, Dai Gengsun, Yin Xuenian, Xu Jiujin, Du Ruofu. Genetic polymorphism of Gc, PGM1, AcP1 , 6-PGD, ADA and AK1 in She ethnic group in China[J]. Acta Anthropologica Sinica, 1997, 16(04): 262-270.