中国5个民族亚甲基四氢叶酸还原酶基因多态性的研究

人类学学报 ›› 1998, Vol. 17 ›› Issue (03): 242-246.

• 人类学学报 • 上一篇

中国5个民族亚甲基四氢叶酸还原酶基因多态性的研究

于佳梅,王新春,陈白滨,张贵寅,李璞,孙艳阳,薛雅丽,杨焕杰

出版日期:1998-09-15 发布日期:1998-09-15

Study on the mthfr gene polymorphism of five nationalities in China

Yu Jiamei, Wang Xinchun, Chen Baibin, Zhang Guiyin, Li Pu, Sun Yanyang, Xue Yali, Yang Huanjie

Online:1998-09-15 Published:1998-09-15

摘要/Abstract

摘要： 本文利用聚合酶链反应－限制性片段长度多态性（PCR－RFLP）方法，检测了79名汉族、30名鄂伦春族、31名鄂温克族、31名达斡尔族、29名壮族随机选择正常个体亚甲基四氢叶酸还原酶基因677位核苷酸多态性并加以比较。结果表明，该位点多态频率具有种族差异，国内外11个人群中，中国达斡尔族与汉族突变型等位基因V频率最高，分居第一位和第二位，提示亚洲人该频率偏高。

关键词: 亚甲基四氢叶酸还原酶基因;PCR－RFLP;等位基因频率

Abstract: This report used PCR-RFLP technique to screen 79 persons o f Han Nationality, 30 persons of Oroqen, 31 persons of Ewenki, 31 persons of Daur and 29 persons of Zhuang Nationality , all were randomly selected and healthy. Their MTHFR 677 site polymorphisms w ere detected and compared with each other.
Our results show ed that the polymorphic frequencies of this site are different among ethnic groups. Among 11 groups of Chinese and foreign populations, the V frequency o f Chinese Daur Nationality is highest, follow ed by that o f Han. This suggested that the frequencies of the variant V were higher in Asian groups.

Key words: Methylenetetrahydrofolate Reductase Gene, PCR-RFLP, Allele frequency

于佳梅,王新春,陈白滨,张贵寅,李璞,孙艳阳,薛雅丽,杨焕杰. 中国5个民族亚甲基四氢叶酸还原酶基因多态性的研究[J]. 人类学学报, 1998, 17(03): 242-246.

Yu Jiamei, Wang Xinchun, Chen Baibin, Zhang Guiyin, Li Pu, Sun Yanyang, Xue Yali, Yang Huanjie. Study on the mthfr gene polymorphism of five nationalities in China[J]. Acta Anthropologica Sinica, 1998, 17(03): 242-246.

中国5个民族亚甲基四氢叶酸还原酶基因多态性的研究

Study on the mthfr gene polymorphism of five nationalities in China

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