中国4个少数民族中SDF1多态性研究

人类学学报 ›› 2002, Vol. 21 ›› Issue (04): 311-314.

中国4个少数民族中SDF1多态性研究

张春玉,薛雅丽,黄小义,马琳琳,于旸,刘岸,吕芙蕖,李璞,傅松滨

出版日期:2002-12-15 发布日期:2002-12-15

Study on polymorphism of the SDF1 allele in 4 ethnic groups of China

ZHANG Chun-yu; XUE Ya-li; HUANG Xiao-yi; MA Lin-lin; YU Yang; LIU An; L Fu-qǜ; LI Pu; FU Song-bin

Online:2002-12-15 Published:2002-12-15

摘要/Abstract

摘要： 研究与HIV 1感染相关的基质细胞衍生因子 (SDF1)等位基因突变频率和多态性在中国 4个少数民族的分布特征。应用PCR/ RFLP等方法检测回族 (5 7例 )、鄂伦春族 (71例 )、蒙古族 (30例 )及锡伯族 (2 6例 )共 184个个体中SDF1 -3’A基因突变频率。结果得出中国 4个民族中SDF1- 3’A基因的基因频率分别为 :蒙古族为 38 3%,锡伯族为 2 3 .1%,回族为 2 0 .2 %,鄂伦春族为 10 .6 %。中国 4个少数民族中SDF1- 3’A等位基因频率存在较大的差异 (χ2 =37 .82 6 ,P<0.01) , 提示这 4 个民族的遗传结构存在着一定的差异。本研究为评估中国不同民族对 HIV-1 的易感性及艾滋病的流行病学研究提供了基本数据。

关键词: 人类免疫缺陷病毒1; 基质细胞衍生因子; 基因突变; 多态性

Abstract: To study the mutant frequency and polymorphism of stromal derived factor-1 (SDF-1) con- ferring resistance to determined HIV-1 AIDS in 4 ethnic groups in China.The studied population in- cluded 184 subjects, of which consisted the Hui (n =57), the Oroqen (n =71), the Mongolian (n = 30), the Xibe (n =26). The genotype of the SDF1-3' A was detected by PCR RFLP with the digestion of restriction endonuclease Msp I. The frequency of SDF1-3' A mutant allele was :38.3 %of theMon- golian, 23.1 %of the Xibe, 20.2 %of the Hui and 10.6 %of the Oroqen. The difference of SDF1-3' A polymorphisms were found in 4 ethnic groups in China.

Key words: HIV-1; SDF1; Gene mutation; Polymorphism

张春玉,薛雅丽,黄小义,马琳琳,于旸,刘岸,吕芙蕖,李璞,傅松滨. 中国4个少数民族中SDF1多态性研究[J]. 人类学学报, 2002, 21(04): 311-314.

ZHANG Chun-yu; XUE Ya-li; HUANG Xiao-yi; MA Lin-lin; YU Yang; LIU An; L Fu-qǜ; LI Pu; FU Song-bin. Study on polymorphism of the SDF1 allele in 4 ethnic groups of China[J]. Acta Anthropologica Sinica, 2002, 21(04): 311-314.