新疆维、哈、蒙古族5-HTT基因启动子区多态性的研究

人类学学报 ›› 2007, Vol. 26 ›› Issue (03): 259-263.

新疆维、哈、蒙古族5-HTT基因启动子区多态性的研究

乔艳辉;马合木提.哈力克;左宏莉;吐尔洪.克维尔;多力坤.买买提玉素甫

出版日期:2007-09-15 发布日期:2007-09-15

A study of the serotonin transporter-linked promoter region polymorphism in Xinjiang Uygur, Kazak, and Mongol Ethnic Group

QIAO Yanhui, MahmutHalik, ZUO Hongli, TuerhongKewer, DolkunMamatyusupu

Online:2007-09-15 Published:2007-09-15

摘要/Abstract

摘要： 采用聚合酶链反应(PCR)技术,对我国新疆维吾尔族、哈萨克族和蒙古族三个正常群体5-HTT基因启动子区(5-HTTLPR)的一个插入/缺失多态性进行了研究。结果显示:5-HTTLPR等位基因及基因型频率分布在三个民族中没有较大差异,短片段等位基因S有较高的分布频率。X2检验证明,三个民族群体的基因型分布均符合Hardy-Weinberg平衡(P>0.05)。经分析,维吾尔族的观测杂合度(Hobs)、期望杂合度(Hexp)、多态信息量(PIC)分别为0.4167、0.4845和0.3759;哈萨克族的Hobs、Hexp和PIC分别为0.4141、0.4338和0.3396;蒙古族的Hobs、Hexp和PIC分别为0.4639、0.4386和0.3425。结果可为人类学、法医学鉴定及疾病的关联研究提供遗传学数据。

关键词: 5-HTTLPR;多态性;维吾尔族;哈萨克族;蒙古族

Abstract: The insertion/deletion polymorphism of the serotonin transporter-linked promoter region ( 5-HTTLPR) was studied using the polymerase chain reaction ( PCR) method in Xinjiang Uygur, Kazak, and Mongol ethnic groups. The results showed that there were no significant differencies in the distributions of the 5-HTTLPR genotype and allele frequencies among the three ehhnic groups. It should be noted that the short allele S had a higher frequency. X2 tests indicated that their distribution of genotypes was consistent with theHardy-Weinberg equillibrium( P > 0.05) . Statistical analysis gave the results: Observed heterozygosity (Hobs) , expected heterozygosity ( Hexp ) and polymorphism information of 5-HTTLPR from the Uygur ethnic group were 0.4167, 0.4845 and 0.3759; and those from Kazak ethnic group were 0.4141, 0.4338 and 0.3396; and those from Mongol ethnic group were 0.4639, 0.4386 and 0.3425. These results provide important group genetics information for forensic identification, anthropological and disease association studies.

Key words: 5-HTTLPR; Polymorphism; Uygur; Kazak; Mongol

乔艳辉;马合木提.哈力克;左宏莉;吐尔洪.克维尔;多力坤.买买提玉素甫. 新疆维、哈、蒙古族5-HTT基因启动子区多态性的研究[J]. 人类学学报, 2007, 26(03): 259-263.

QIAO Yanhui, MahmutHalik, ZUO Hongli, TuerhongKewer, DolkunMamatyusupu. A study of the serotonin transporter-linked promoter region polymorphism in Xinjiang Uygur, Kazak, and Mongol Ethnic Group[J]. Acta Anthropologica Sinica, 2007, 26(03): 259-263.