Abstract: Distribution of eight blood groups in Han ethnic group of Guizhou province was studied. P1 (0.1520) and Dia (0.0182) gene frequencies in Guizhou Han ethnic group are lower than those in other Han subgroups. The gene frequencies of other blood groups are p= 0.2171, q=0.1858, r=0.5969, m= 0.5400, n=0.4600, Jk2 = 0.4633, Jkb= 0.5367, Fy2= 0.9367, Fyb= 0.0633, halpotype frequencies are MS = 0.0301,NS = 0.0177,Ms = 0.5099, Ns= 0.4423, R1 = 0.5766, R2 = 0.2508, R0= 0.0511, Rz = 0.0421,r' = 0.0794. No Fy (a-) phenotype was found.

Key words: Physical anthropology; Blood groups; Phenotype frequency; Gene frequency; Han ethnic group