Abstract: To study the mutant frequency and polymorphism of stromal derived factor-1 (SDF-1) con- ferring resistance to determined HIV-1 AIDS in 4 ethnic groups in China.The studied population in- cluded 184 subjects, of which consisted the Hui (n =57), the Oroqen (n =71), the Mongolian (n = 30), the Xibe (n =26). The genotype of the SDF1-3' A was detected by PCR RFLP with the digestion of restriction endonuclease Msp I. The frequency of SDF1-3' A mutant allele was :38.3 %of theMon- golian, 23.1 %of the Xibe, 20.2 %of the Hui and 10.6 %of the Oroqen. The difference of SDF1-3' A polymorphisms were found in 4 ethnic groups in China.

Key words: HIV-1; SDF1; Gene mutation; Polymorphism