Abstract: Polymorphisms of three selected miniSTR loci, D10S1248, D14S1434, and D22S1045, were investigated in 141 Han ethnic people from northeastern Chinese populations. Multiple fluorescent polymerase chain reaction (PCR) techniques were performed for the three loci in one tube per individual sample, with the genotypic information obtained using an ABI 310 Genetic Analyzer with capillary electrophoresis. A total of 25 alleles and 56 genotypes were detected in the 3 miniSTR loci, and their frequency distributions showed no significant deviations from the Hardy-Weinberg equilibrium. Each of the three miniSTR loci showed high levels of heterozygosity, discrimination power, and power of exclusion. The accumulated power of discrimination and exclusion for the three loci was 0. 99876 and 0. 89819, respectively. The results of this study indicate that a high level of genetic polymorphisms can be observed in Han ethnic Chinese of Northeastern China when using the three loci selected. This research would be helpful in future population studies, and in forensic analyses.

Key words: MiniSTR; Genetic polymorphisms; Allele; Han; Northeastern China