Abstract: The phenotypes of a1-AT were determinded for Chinese Han and six Chinese national minorities including Mongolian, Korean, Manchurian, Tahur, Owenkand Olunchun nationalities, The frequencies of PiM and Pivariant alleles were not significantly different between Han population and these national minorities. PiEtokyo allele is the most common a1-AT variant and Piz is absent in all the Chinese population observed by us, and one heterozygote was found in Olunchun nationality, showing certain evidence for studying the ties of blood between Chinese Han population and these Chinese national minorities.

Key words: α1-AT; Polymorphism; National minority in China