Abstract: The distribution of red cell blood group systems, including ABO, MNSs, Rh, Kidd,Duffy, Dicgo, Xg, Lewis and P was investigated on 200 healthy Hakka students whose parents and grandparents are Hakkas too. The frequencies of 14 alleles and 11 haplotypes of10 blood group loci showed that the gene frequencies S(0.02S0), NS(0), P(0.0917) and Fy'(0.0300) in Hakka appeared to be the lowest among Han subpopulations. Other gene frequencies were as follows: r= 0.6632, p= 0.1863, q= 0.1505; m= 0.5250, n= 0.4750,MS= 0.0250, Ms= 0.5000, Ns= 0.4750, s= 0.9750; C= 0.6575, D= 1 .0000, E= 0.1515,CDe= 0.6226, cDE= 0.1200, cDe= 0.2189, CDE= 0.0389; Jk^a= 0.4642, Jk^b= 0.4881,Jk= 0.0477; Fy^a= 0.9700; Di^a= 0.0202, Di^b = 0.9798; Xg^a= 0.3633, Xg = 0.6367; P2= 0.9083.A Jk(a-b-) type was found. At the same time, no MNS, NS, NSs, CCDEE, CcDEE,Fy(a-) and Rh,(-) types were observed. Thc Lewis system showed the following phenotypedistribution: Le(a+b-) 29 (14.5% ), Le (a+b+) 2 (1.0% ), Le(a-b+) 67 (33.5% ) and Le(a-b-) 102 (51.0%).
The genetic distance between Hakka and 19 populations in China showed that theHakka is genetically closc to Han in Fujian and Guizhou, Miao in Hunan and Dong inGuangxi, and quite close to Han in Henan, Heilongjang, Shaanxi, Shanghai and Shezu inFujian. At the same time, the Hakka is genetically far from Han in Inner M ongolia andGansu, as well as Zhuang and Yao in Guangxi, Yi in Sichuan, Bai in Yunnan and Man inLiaoning, and has the farthest genetic distance with Li and Miao in Hainan, and Tujia inHunan.

Key words: Red cell blood groups; Han; Hakka; Gene frequency; Genetic distance