Abstract: In present study after extracting genomic DNA from four population DNA fragment of the fourth exon of apo E, which contains site 112 and 158 in amino acid sequence, were amplified by PCR-RFLP and conducted polymorphism analysis. The results showed that the distribution tendency of apo E allele frequency in four populations ( the Han, the Daur, the Oroqen and the Ewenki) is similar to that reported home and abroad, but the frequency of alleleε3 is significantly higher than that of Europe and American populations.

Key words: Apolipoprotein E, Genetic Polymorphism, PCR-RFLP